Cambridge暑期化学纳米科学和应用科研学术项目Chemistry（寒暑假项目）

课程详情：

一、课程概览 
为了拓宽化学拔尖学生学术视野，推动“化学+”的跨学科交叉人才培养，四川大学化学学院与剑桥大学联合开展2020年暑期定制课程。课程内容主要围绕剑桥大学优势研究方向。单分子荧光检测和纳米扫描探针合成展开，单分子检测是近十年来迅速发展起来的一种超灵敏的检测技术，通过课程学习帮助学生理解该领域的研究内容和方向，拓展学生化学领域认知范围，了解未来在这些领域中可选择的研究方向和应用范畴。 课程将采用剑桥大学独特的教学方式，通过讲座+讨论的形式帮助学生更深入地理解课程内容，实现从理论学习到应用拓展的延伸，同时培养学生的批判思维能力和理解分析能力。 
二、课程具体将从以下内容展开： 
Course outline: Recent advancements in nanoscience and technology The following course is designed to stimulate the interest of undergraduates studying Chemistry to perform cutting-edge interdisciplinary research in nanotechnology with applications in physics and biology. The course is divided into 2 parts: the first covering traditional and recent methodologies to fabricating nanostructures and their applications in biology and physics and the second covering tools for observing and manipulating nanoobjects. Emphases is placed on the lecturer’s research at top research and academic institutes (Oxford, Cambridge, MPI) in biophysical chemistry and particularly nanobioimaging. The lecturer will strongly adopt a two-way engagement-based teaching methodology by allowing small groups of students to research and present some of the topics outlined below on top of their final assessment.  
 
Note: 1.5 hours are dedicated for the final presentation. （18课时中1.5个小时用于最后学生进行期末展示给分）
 
1. Micro and nano fabrication

a. Methods for micro and nano fabrication (1.5 hour)

i. Deposition-based technologies.

ii. Micro and nano lithography.

iii. Nanopatterning.

iv. Printing, self-assembly and self-intercalation.

v. Single- and dual- step self-templating of microparticles.

b. Physical nanoobjects and their applications (2 hours)

i. Mirrors from single atomic layers.

ii. Combining electronic and optoelectronic functionalities on a single chip.

 iii. Stress-free Carbon nanotubes.

iv. Flexible electronics. v. Single molecule electric motors.

vi. Nanoantennas.

c. Biological nanoobjects and their applications (1.5 hours)

i. 3D-printing complete tissues; cell-by-cell.

ii. Building up a minimal cell model.

iii. Nanoboxes and patterns made from DNA.

iv. Artificial cellular membranes.

v. Molecular trains from chemical hoppers.

2. Characterizing and visualizing matter at the nanoscale

a. Physical characterization techniques (1 hour)

i. Transmission Electron Microscopy (TEM)

ii. Scanning Electron Microscopy (SEM)

iii. Dynamic Light Scattering (DLS)

iv. Scanning Tunneling Microscopy (STM)

b. Biological imaging and manipulation tools

i. Label-free technologies (1 hour) 1. Atomic Force Microscopy (AFM). 2. Cryogenic Electro Microscopy (Cryo-EM). 3. Interferometric Scattering Microscopy (iSCAT).

ii. Single molecule and super-resolution nanoscopes (2.5 hours) 1. Counting, tracking, distancing and manipulating molecules at the molecular and nano scales. 2. Seeing is believing: super-resolving biological structures smaller than 10 nm.

iii. Biological and biomedical applications to nanobioimaging (2.5 hours) 1. Weighing biomolecules using light. 2. Measuring the weight of cells with picogram resolution. 3. Imaging the periodicity of the cytoskeleton. 4. Watching ion channels in action. 5. Early diagnosis of Alzheimer’s and Parkinson’s. 6. Tracking viral entry at the nanoscale. 7. Sequencing the genome with light. 8. Structural biology with photons. 9. Coiling and uncoiling DNA molecules. 10. Pull-and-Paste single proteins. 

三、课程简介

Dr John Danial
剑桥大学化学系讲师、研究生导师
剑桥大学国王学院研究员、Klenerman实验室研究员
牛津大学物理化学、理论化学博士，Weidenfeld-Louis Drefus奖学金获得者
曾就职于德国杜宾根大学普朗克研究院。
主要研究方向包括设计和建构高通量超高分辨率显微镜用以分析蛋白质聚集。曾开发出用于定量分析超分辨率结构的计算工具

四、课程安排

课时：18个课时，每个课时45分钟
时间：具体课程时间可定制
○    一般在中国时间下午4点到5点半、及（或）七点到八点半）
○    可根据学生时间与授课老师尽量进行微调。

项目优势：
1. 课程为本科生大三、大四的学生所设置，学习最新最前沿的科技、技术和了解最新科研方向

2. 课程可根据国内师生的需求做时间上和内容微调

3. 学生将获得学分和证书

4.与剑桥教授面对面交流

5. 项目增加如何申请剑桥研究生项目和全面了解剑桥大学的历史和现状讲座，为同学们全面深入了解世界一流学府提供宝贵机会。